Mutual repression between steroid and xenobiotic receptor and NF- B signaling pathways links xenobiotic metabolism and inflammation
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چکیده
منابع مشابه
Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation
1Department of Developmental and Cell Biology, 2Department of Medicine, and Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA. 3Department of Gene Regulation and Drug Discovery, City of Hope National Medical Center, Beckman Research Institute, Gonda Diabetes Research Center, Duarte, California, USA. 4Department of Pharmaceutics, Universi...
متن کاملMutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.
While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to xenobiotic chemicals can impair immune function, the molecular mechanisms underlying both of these phenomena have remained largely unknown. Here we show that activation of the nuclear steroid and xenobiotic receptor (SXR) by...
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The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian species and SXR exhibits considerable differ...
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(Petters et al., 1983) permits the determination of small amounts of 7-aminoclonazepam (about 20 pmol) and is thus useful for measuring low activities in various tissues. All investigated foetal livers catalysed the nitroreduction reaction at different rates. The mean activity was in the same range as that in Rhesus monkey liver, but only about 15% of the activity in human adult liver. Such dis...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2006
ISSN: 0021-9738
DOI: 10.1172/jci26283